N, N'-Methylenebisacrylamide Cas: 110-26-9 98% Farin foda
| Lambar Catalog | Saukewa: XD90231 |
| Sunan samfur | N, N'-Methylenebisacrylamide |
| CAS | 110-26-9 |
| Tsarin kwayoyin halitta | Saukewa: C7H10N2O2 |
| Nauyin Kwayoyin Halitta | 154.1665 |
| Bayanin Ajiya | 2 zuwa 8 ° C |
| Harmonized Tariff Code | 29241900 |
Ƙayyadaddun samfur
| Assay | >98% |
| Ruwa marar narkewa | <0.5% |
| Bayyanar | Farin foda |
| Inorganic sulfates | <0.5% |
| Don amfani da bincike kawai, ba don amfanin ɗan adam ba | amfani da bincike kawai, ba don amfanin ɗan adam ba |
Muhimmiyar rawa na fibroblasts masu alaƙa da ƙari (TAF) a cikin ci gaban kansa yanzu a bayyane yake a cikin ciwon huhu mara ƙananan ƙwayoyin cuta (NSCLC).Koyaya, hanyoyin kwantar da tarzoma akan TAFs suna da iyaka saboda rashin fahimta a cikin takamaiman hanyoyin ƙayyadaddun nau'ikan da ke tattare da tara su.Anan, injina (watau matrix rigidity) da alamomin mitogenic masu narkewa waɗanda ke fitar da tarin TAFs daga manyan nau'ikan NSCLC: adenocarcinoma (ADC) da squamous cell carcinoma (SCC) an rarraba su.Fibroblasts an ɗora al'ada a kan kayan aikin da aka yi amfani da su don nuna rashin ƙarfi na al'ada-ko kamar ƙwayar cuta a cikin nau'o'in jini daban-daban, kuma an bayyana matakai masu mahimmanci.A cikin sarrafa fibroblasts daga nama mara kyau, matrix stiffening kadai ya karu tarin fibroblast, kuma wannan tasirin injin ya kasance mai rinjaye ko kwatankwacin na abubuwan haɓaka mai narkewa har zuwa 0.5% serum.Alamu masu ƙarfafawa na matrix rigidity an motsa su ta hanyar β1 integrin mechano-sensing ta hanyar FAK (pY397), kuma an haɗa su tare da haɓakawa bayan an rubuta su a cikin β1 integrin magana.An kuma lura da da'irar mechano-regulatory na ƙarshe a cikin TAFs amma a cikin takamaiman nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau’in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau‘in nau'in nau'in nau'in nau'in nau‘in nau'in nau'in nau'in nau'in nau'i, saboda SCC-TAFs sun nuna mafi girman FAK (pY397), β1 magana, da ERK1/2 (pT202/Y204) fiye da ADC-TAFs.Haka kuma, taurin matrix ya haifar da tarin TAF mafi girma a cikin SCC-TAFs (> 50%) idan aka kwatanta da ADC-TAFs (10% -20%).Sabanin haka, SCC-TAFs ba a rage yawan jini ba, yayin da ADC-TAFs suka amsa ga babban taro kawai.Waɗannan binciken sun ba da shaida ta farko na ƙayyadaddun ƙa'idodin ƙayyadaddun ƙayyadaddun ƙa'idar NSCLC-TAF.Bugu da ƙari kuma, waɗannan bayanan suna goyan bayan cewa hanyoyin kwantar da hankali da ke da nufin mayar da elasticity na huhu na al'ada da / ko β1 ka'idar mechano mai dogara da haɗin gwiwa na iya zama tasiri a kan SCC-TAFs, yayin da hana siginar haɓakar ƙwayar cuta na iya zama tasiri a kan ADC-TAFs. rashin daidaituwa na tarin fibroblasts masu tallafawa ƙari a cikin manyan nau'ikan nau'ikan ciwon huhu guda biyu, wanda zai taimaka haɓaka hanyoyin kwantar da hankali akan waɗannan ƙwayoyin.
