Kayayyaki

Flow cytometry hanya ce ta haƙiƙa don gudanar da gwaje-gwajen ji na cutar maleriya a cikin vitro tare da haɓaka yuwuwar aikace-aikace a rukunin yanar gizo.Mun yi nazarin rashin lafiyar in vitro zuwa magungunan zazzabin cizon sauro guda bakwai don 40 sabo P. falciparum filin keɓe ta hanyar hanyar cytometry mai gudana (FCM), ELISA mai launi na LDH mai launi: DELI), da kuma daidaitaccen nazarin zane-zane na microscopic na girma.Don FCM, 184/280 (66%) kimantawa sun cika sharuddan karɓa na nazari, idan aka kwatanta da 166/280 (59%) don DELI.An sami kyakkyawar yarjejeniya tsakanin FCM da microscopy, yayin da DELI ke son samar da mafi girman matsakaicin hana hanawa na rabin-maximal (IC50s) fiye da FCM, tare da nuna son kai na 2.2-ninka (kwatancen Bland-Altman).Ƙimar artesunate da dihydroartemisinin sun fi shafa.Haɓakawa a cikin sigina a babban adadin mefloquine da mahaɗan da ke da alaƙa sun fi alama da gwajin DELI, yana ba da shawarar cewa tasirin da ba a kai ba akan samarwa LDH na iya zama alhakin.Asarar siginar FCM saboda sake mamayewa ko jinkirin girma an lura da shi a cikin ƙaramin adadin samfuran.Waɗannan sakamakon sun ƙaddamar da aikin da ya gabata akan amfani da cytometry mai gudana don ƙayyade yiwuwar kamuwa da cutar maleriya dangane da adadin samfuran, kewayon magunguna, da kwatanta da sauran hanyoyin.