Kayayyaki

Ana iya amfani da Nicotinamide Riboside a cikin nazarin nazarin halittu na kwayar halittar reprogramming transcriptome a cikin hanta da aka gano hanyoyin rayuwa na tsufa a cikin linzamin kwamfuta.Hakanan yana ƙara NAD + a cikin ƙwayar ƙwayar cuta kuma yana rage fahimi tabarbarewar a cikin ƙirar linzamin kwamfuta ta transgenic na cutar Alzheimer.

Nicotinamide adenine dinucleotide (NAD +) wani coenzyme ne mai mahimmanci wanda, lokacin da aka rage shi zuwa NADH, yana aiki azaman wakili mai ragewa don ba da gudummawar electrons don phosphorylation oxidative da haɗin ATP a cikin mitochondria.NAD + shine mahimmin cofactor don enzymes kamar sirtuins, ADP-ribosyltransferases (ARTs), da Poly [ADP-ribose] polymerases (PARPs) kuma waɗannan enzymes suna ci gaba da cinye su.Matsakaicin NAD+/NADH muhimmin sashi ne na yanayin sake fasalin tantanin halitta.(Verdin 2015).Ta wasu ƙididdiga, NAD ko NADP masu alaƙa suna shiga cikin kashi ɗaya cikin huɗu na duk halayen salula (Opitz Heiland 2015).Akwai sassa daban-daban na NAD + a cikin tsakiya, mitochondria, da cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) za a iya canzawa zuwa NAD + ta hanyar matsakaiciyar mataki wanda aka canza shi zuwa nicotinamide mononucleotide (NMN) ta NR kinase (Nrk) sannan zuwa NAD + ta NMNATs.Ana samun NR ta dabi'a a cikin wasu abinci amma a cikin adadi kaɗan (misali ƙananan kewayon micromolar).A tarihi, NR yana da wahala a samu a cikin adadi mai yawa, amma godiya ga ci gaban hanyoyin haɗin gwiwa (Yang 2007), kamar na Yuni 2013, ana sayar da shi azaman kari na abinci.