Kayayyaki

Nasarar gyare-gyaren myelin a cikin babban CNS yana buƙatar samar da ƙaƙƙarfan ƙaƙƙarfan sunadaran myelin don samar da sabon sheath na myelin.Mahimman hanyoyin sarrafawa da kuma hadadden tushen kwayoyin halitta na farfadowa na myelin, duk da haka, sun kasance marasa fahimta.Anan, mun bincika rawar ERK MAP kinase siginar a cikin wannan tsari.Shafewar yanayi na Erk2 daga sel na layin oligodendrocyte ya haifar da jinkirin jinkirin bayan raunin demyelinating ga babban linzamin kwamfuta corpus callosum.Gyaran da aka jinkirta ya faru ne sakamakon wani ƙayyadadden rashi a cikin fassarar babban furotin na myelin, MBP.Idan babu ERK2, kunna furotin na ribosomal S6 kinase (p70S6K) da maƙasudinsa na ƙasa, furotin na ribosomal S6 (S6RP), ya lalace a wani lokaci mai mahimmanci lokacin da premyelinating oligodendrocytes ke canzawa zuwa sel balagagge masu iya haifar da sabon myelin sheaths.Don haka, mun bayyana wata muhimmiyar hanyar haɗi tsakanin ERK MAP kinase siginar cascade da injunan tra nslational musamman a cikin remyelinating oligodendrocytes a cikin vivo.Wadannan sakamakon suna ba da shawarar muhimmiyar rawa ga ERK2 a cikin fassarar fassarar MBP, furotin na myelin wanda ya bayyana mahimmanci don tabbatar da lokaci na sabon sheaths na myelin bayan raunin demyelinating a cikin CNS mai girma.