Kayayyaki

Nickel shine mai kayyade ƙwayar cuta ga ƙwayoyin cuta na ciki na ɗan adam Helicobacter pylori.Hakika, H. pylori yana da nau'in nickel-enzymes guda biyu waɗanda suke da mahimmanci ga mulkin mallaka na vivo, [NiFe] hydrogenase da urease, wani nau'in ƙwayar cuta mai yawa wanda ya ƙunshi 24 nickel ions a kowace hadaddun aiki.Saboda waɗannan enzymes guda biyu, rayuwa na H. pylori ya dogara ne akan wani muhimmin samar da nickel, yana nuna tsananin sarrafa rarrabawa da ajiyarsa.A cikin wannan bita, za mu gabatar da hanyoyin kunna enzymes na nickel da kuma hanyoyin da aka samo a cikin H. pylori don ɗauka, fataucin da rarraba nickel tsakanin enzymes guda biyu.Waɗannan sun haɗa da (i) tsarin karɓar nickel na waje, mai jigilar FrpB4 TonB, (ii) rukunin furotin da ke da alaƙa da haɗin gwiwar fataucin nickel da rarraba tsakanin urease da hydrogenase da, (iii) Helicobacter takamaiman sunadaran nickel masu ɗaurewa. waɗanda ke da hannu a cikin ajiyar nickel kuma suna iya taka rawar metallo-chaperones.A ƙarshe, za mu tattauna tasirin abokan hulɗar fataucin nickel a cikin ƙwayoyin cuta kuma mu ba da shawarar su azaman sabbin dabarun warkewa don maganin cutar H. pylori.