Uridine-5′-diphosphoglucuronic acid trisodium gishiri CAS: 63700-19-6 Farin foda
| Lambar Catalog | Saukewa: XD90382 |
| Sunan samfur | Uridine-5'-diphosphoglucuronic acid trisodium gishiri |
| CAS | 63700-19-6 |
| Tsarin kwayoyin halitta | Saukewa: C15H19N2O18P2Na3 |
| Nauyin Kwayoyin Halitta | 646.20 |
| Bayanin Ajiya | <-4 °C |
Ƙayyadaddun samfur
| Assay | 99% |
| Bayyanar | Farin foda |
Binciken na yanzu yana nufin bincika tasirin gubar irinotecan ta hanyar canza yanayin glucoaurantio-obtusin zuwa aurantio-obtusin.Gudanar da intraperitoneal (ip) na 100 mg / kg aurantio-obtusin yana haɓaka yawan guba na irinotecan, amma gudanarwar ip na 100 mg / kg glucoaurantio-obtusin ya nuna tasiri mara kyau ga irinotecan ta guba.Bugu da ƙari kuma, an bayyana tsarin ta hanyar ƙayyade yiwuwar hana glucoaurantio-obtusin da aurantio-obtusin zuwa ga glucuronidation metabolism na SN-38 wanda aka dauka a matsayin babban samfurin aiki wanda ke da alhakin guba na irinotecan.Sakamakon ya nuna cewa aurantio-obtusin ya nuna babban hana gasa ga glucuronidation na SN-38, amma yuwuwar hanawa na glucoaurantio-obtusin zuwa SN-38 glucuronidation an lura.Wadannan sakamakon sun nuna cewa biotransformation na glucoaurantio-obtusin zuwa aurantio-obtusin ya karu da guba na irinotecan ta hanyar haɓakar hana SN-38 glucuronidation.
