Kayayyaki

Yin jiyya na ƙwayoyin dabbobi masu shayarwa tare da magungunan chemotherapeutic na iya haifar da rikicewar wuraren tafkunan nucleotide.Kula da waɗannan rikice-rikice a cikin ƙwayoyin ƙwayar cuta na al'ada daga tushen ɗan adam yana da amfani don kimanta tasirin maganin miyagun ƙwayoyi da ingantaccen fahimtar tsarin aikin waɗannan magunguna.A cikin wannan binciken, an yi amfani da nau'o'i uku na magungunan chemotherapeutic tare da hanyoyi daban-daban na aiki a cikin ci gaba da nau'in kwayoyin halitta.Binciken metabolomics na tushen LC da aka yi niyya na nucleotides a cikin sel na ƙungiyar kulawa da ƙungiyar da aka yi wa magani.An haɗu da hanyoyin sarrafa bayanai da yawa don gano yuwuwar alamun halittu masu alaƙa da aikin magunguna, gami da nazarin bambance-bambancen hanya ɗaya, ƙididdigar babban ɓangaren, da maɓallan halayen mai karɓar aiki.Abin ban sha'awa, ƙwayoyin tumor duka ƙungiyar kulawa da ƙungiyoyi masu maganin miyagun ƙwayoyi za a iya bambanta da juna, kuma an gane yawancin masu canji a matsayin masu amfani da kwayoyin halitta, irin su ATP, GMP, da UDP don magungunan antimetabolite, ATP, GMP, da CTP. ga ma'aikatan da ke lalata DNA, da kuma GMP, ATP, UDP, da GDP don ma'aikatan sinadarai na mitotic.An yi ƙarin tabbatar da yuwuwar alamun halittu ta amfani da madaidaicin yanayin aiki mai karɓa.Idan aka yi la'akari da yankin da ya dace da su a ƙarƙashin lanƙwasa, wanda ya fi girma fiye da 0.9, ana iya ƙaddamar da cewa GMP da ATP sune mafi kyawun masu amfani da kwayoyin halitta don lalata DNA, da kuma GMP, ATP, da UDP don sauran nau'o'in kwayoyi guda biyu.Wannan ƙayyadaddun tsarin nucleotide ba zai iya bambance gaba ɗaya hanyoyin hanyoyin magungunan tara ba, amma yana ba da shaidar farko don rawar pharmacometabolomics a cikin haɓakar ƙwayoyin magunguna aƙalla.