Kayayyaki

tRNA shine nau'in nau'in RNA da aka fi gyara sosai, kuma ana samun gyare-gyare a cikin tRNAs daga dukkan halittun da aka bincika.Duk da ɗimbin tsarin sinadarai daban-daban da kasancewarsu a cikin tRNA daban-daban, waɗanda ke faruwa a wurare daban-daban a cikin tRNA, hanyoyin biosynthetic na yawancin gyare-gyaren tRNA sun haɗa da matakin methylation.Binciken da aka yi kwanan nan ya bayyana rikitarwa da ba a taɓa ganin irinsa ba a cikin gyare-gyaren tsarin tRNA, tsarin su da aikinsu, yana nuna cewa kowane nucleoside da aka gyara a cikin tRNA na iya samun takamaiman aikin sa.Koyaya, a cikin tsire-tsire, iliminmu akan rawar mutum-mutumin gyare-gyaren tRNA da yadda ake sarrafa su yana da iyaka.A cikin allon kwayoyin halitta da aka tsara don gano abubuwan da ke daidaita juriya da cututtuka da kunna kariya a cikin Arabidopsis, mun gano SUPPRESSOR OF CSB3 9 (SCS9).Sakamakonmu ya bayyana SCS9 yana ɓoye tRNA methyltransferase wanda ke daidaita 2'-O-ribose methylation na nau'in tRNA da aka zaɓa a cikin madauki na antico don madauki.Wadannan gyare-gyaren tRNA na SCS9 suna haɓaka lokacin kamuwa da cuta tare da ƙwayoyin cuta pathogen Pseudomonas syringae DC3000, da kuma rashin irin wannan gyare-gyaren tRNA, kamar yadda aka gani a cikin mutants na scs9, suna lalata rigakafi na shuka daga pathogen guda ba tare da rinjayar salicylic acid (SA) ba. hanyar da ke daidaita martanin rigakafin shuka.Sakamakonmu yana goyan bayan ƙirar da ke ba da mahimmanci ga sarrafa wasu gyare-gyare na tRNA don haɓaka ingantaccen martani na rigakafi a cikin Arabidopsis, don haka yana faɗaɗa bayanan abubuwan da ke cikin kwayoyin mahimmanci don ingantaccen martanin juriya na cuta.