A gaban 2.8 mM D-glucose, beta-D-glucose pentaacetate (1. 7 mM) ƙarar sakin insulin daga keɓaɓɓen tsibiran pancreatic fiye da alpha-D-glucose pentaacetate.Hakazalika, ƙarin haɓakar samar da insulin da nateglinide (0.01 mM) ya haifar ya kasance mafi girma a cikin tsibiran da aka fallasa ga beta- maimakon alpha-D-glucose pentaacetate.Sabanin haka, a gaban 2.8 mM D-glucose mara amfani, alpha-L-glucose pentaacetate, amma ba beta-L-glucose pentaacetate, yana haɓaka fitowar insulin sosai.Mafi girman ƙarfin insulinotropic na beta-anomer na D-glucose pentaacetate ya zo daidai da gaskiyar cewa yana haɓaka ƙimar da aka haɗa tsakanin D-[U-14C]glucose oxidation da D-[5-3H] amfani da glucose, yayin da alpha-D. -glucose pentaacetate ya kasa yin hakan.Ana fassara waɗannan binciken don tallafawa ra'ayin cewa haɓakawar sakin insulin ta waɗannan esters galibi ana danganta su da hulɗar kai tsaye tare da mai karɓa na musamman, tare da zaɓi don daidaitawar C1 gama gari zuwa beta-D-glucose pentaacetate da alpha-L- glucose pentaacetate.
