Kayayyaki

BBS4 yana ɗaya daga cikin sunadaran sunadarai da yawa waɗanda lahaninsu ke haifar da ciwo na Bardet-Biedl (BBS), cuta mai yawan tsari, yana bayyana tare da alamar kiba.BBS4 polymorphisms an haɗa su da yawan kiba marasa lahani.Hanyoyin ƙwayoyin ƙwayoyin kiba na BBS4, da kuma rawar BBS4 a cikin bambance-bambancen adipocyte da aiki ba a san su gaba ɗaya ba.Yanzu mun nuna cewa Bbs4 tana taka muhimmiyar rawa a cikin haɓakawa da adipogenesis: shiru na Bbs4 a cikin 3T3F442A preadipocytes sun haifar da haɓakar rarrabuwar sel da bambance-bambancen aberrant, bayyananne ta hanyar nazarin morphologic (haske, dubawa da watsawa ta hanyar microscopy), nazarin rayuwa (taruwa mai kitse). Fatty acid profile da lipolysis) da alamun adipogenic kwafi (Cebpα, Pparγ, aP2, ADRP, Perilipin).Duk cikin adipogenesis kuma lokacin da aka kalubalanci nauyin kitse, Bbs4 sel shiru suna tara ƙarin triglycerides fiye da sarrafa adipocytes, kodayake a cikin ƙananan (har yanzu mafi girma a adadi) ɗigogi masu ɗauke da bayanan martabar fatty acid.Don haka, tarin kitse mai girma a cikin sel da aka yi shiru shine sakamakon duka mafi girma na yaduwar adipocyte da kuma bambance-bambancen da ke haifar da haɓakar tarin kitse na kowane tantanin halitta.Bincikenmu yana ba da shawarar cewa kiba na BBS na iya kasancewa wani ɓangare saboda rawar kai tsaye na BBS4 a cikin hanyoyin ilimin kimiya da ilimin halittar jiki waɗanda ke haifar da samuwar nama mai dacewa da kiba.