Kayayyaki

1. Manufar wannan binciken shine don samar da samfurin pharmacokinetic-pharmacodynamic (PK-PD) mai sauƙi wanda zai iya kwatanta cikakken lokaci na canje-canje a cikin ƙididdigar platelet don tsinkayar farawa da digiri na thrombocytopenia, wanda ke da iyakacin iyakacin amfani da wakilin anticancer 5-fluorouracil (5-FU), a cikin berayen.2. An auna ƙididdigar platelet a cikin berayen da ke bin tsarin kulawa na ciki na nau'i-nau'i daban-daban na 5-FU don kwanaki 4 don samun bayanai don nazarin samfurin PK-PD.Samfurin mu na PK-PD ya ƙunshi samfurin PK mai ɗaki biyu, tare da sassa uku don ƙirar PD da sigogin ƙirar ƙirar PK-PD 10.3. Bayan jiyya na 5-FU, adadin platelet ya ragu da sauri zuwa matakin nadir, ya nuna komawa sama da matakin tushe kafin murmurewa zuwa matakan asali.Nadir platelet kirga da sake dawowa sun bambanta tare da matakin AUC0-∞.Samfurin PK-PD na ƙarshe yadda ya dace ya siffanta bayanan ƙidayar platelet da sigogin PD na ƙarshe da aka kiyasta tare da tabbataccen gaske.4. Wannan samfurin PK-PD da kwaikwaya na iya wakiltar kayan aiki mai mahimmanci don ƙididdigewa da tsinkaya cikakken lokaci na canje-canje a cikin ƙididdigar ƙwayoyin jini, kuma zai iya ba da gudummawa ga ci gaban dabarun warkewa tare da 5-FU da kuma kimantawa na ma'aikatan anticancer daban-daban. wadanda suke da wahalar bincikawa a cikin mutane.